SCHEMBL8548155

SCHEMBL8548155

O=Cc1cnc(Cl)c(C=O)c1Cl

nearest known ligand 0.33

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.33
TDP1 Q9NUW8 2/20 0.33
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2D6 P10635 1/20 0.32
CYP2C19 P33261 1/20 0.32
ERN1 O75460 1/20 0.31
KDM4E B2RXH2 1/20 0.30
MAPT P10636 1/20 0.30
MPI P34949 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19971159 0.82 ERN1 (0.33) ALDH1A1TDP1MEN1KMT2ACYP1A2
SCHEMBL20089295 0.80 ALDH1A1 (0.39) ALDH1A1TDP1MEN1KMT2AERN1
SCHEMBL22729409 0.77 KDM4E (0.38) ALDH1A1TDP1MEN1KMT2ACYP1A2
SCHEMBL15434050 0.77 CYP1A2 (0.38) ALDH1A1MEN1KMT2ACYP1A2CYP3A4
SCHEMBL31447380 0.77 POLB (0.35) ALDH1A1TDP1MEN1KMT2A
SCHEMBL30082527 0.77 KDM4E (0.38) ALDH1A1TDP1MEN1KMT2ACYP1A2
SCHEMBL20571174 0.74 CYP1A2 (0.33) ALDH1A1MEN1KMT2ACYP1A2CYP3A4
SCHEMBL8548859 0.72 PIK3CD (0.39) ALDH1A1TDP1MEN1KMT2AERN1
SCHEMBL25288597 0.72 NFE2L2 (0.37) ALDH1A1TDP1MEN1KMT2AERN1
SCHEMBL20752986 0.72

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0702003-B1 Process for preparing 2-halogenpyridinaldehydes BAYER AG (DE) 1998-06-17 EP disclosed
US-5708180-A CYCLIZATION OF UNSATURATED NITRILE, AMIDE OR OXIME BAYER AKTIENGESELLSCHAFT (DE) 1998-01-13 US disclosed
EP-0702003-A2 Process for preparing 2-halogenpyridinaldehydes and new 2-halogenpyridinaldehydes BAYER AG (DE) 1996-03-20 EP disclosed