Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 13/20 | 0.47 |
| ▸ | EDNRA | P25101 | 6/20 | 0.47 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 2/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8548217 | 0.92 | EDNRB (0.51) | EDNRBEDNRATP53 | |
| SCHEMBL8550894 | 0.90 | EDNRB (0.59) | EDNRBEDNRASRD5A1SRD5A2TP53 | |
| SCHEMBL8551027 | 0.89 | EDNRB (0.53) | EDNRBEDNRAPLK1CTSLCTSB | |
| SCHEMBL8551944 | 0.88 | EDNRB (0.46) | EDNRBEDNRA | |
| SCHEMBL8551621 | 0.87 | EDNRB (0.47) | EDNRBEDNRA | |
| SCHEMBL8552955 | 0.86 | EDNRB (0.52) | EDNRBEDNRASRD5A1SRD5A2PLK1 | |
| SCHEMBL8551476 | 0.85 | EDNRB (0.48) | EDNRBEDNRASRD5A1SRD5A2PLK1 | |
| SCHEMBL8550952 | 0.85 | EDNRB (0.46) | EDNRBEDNRA | |
| SCHEMBL8547935 | 0.84 | EDNRB (0.43) | EDNRBEDNRATP53TSHR | |
| SCHEMBL8552610 | 0.83 | EDNRB (0.46) | EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |