Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 7/20 | 0.43 |
| ▸ | EDNRA | P25101 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.36 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.36 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552639 | 0.91 | EDNRB (0.43) | EDNRBEDNRAALDH1A1MAPTGAA | |
| SCHEMBL8553063 | 0.89 | EDNRB (0.54) | EDNRBEDNRAALDH1A1MAPTKDM4E | |
| SCHEMBL8548217 | 0.88 | EDNRB (0.51) | EDNRBEDNRAALDH1A1MAPTKDM4E | |
| SCHEMBL8551621 | 0.83 | EDNRB (0.47) | EDNRBEDNRAMAPTGAAMEN1 | |
| SCHEMBL8550898 | 0.81 | EDNRB (0.47) | EDNRBEDNRA | |
| SCHEMBL8551944 | 0.81 | EDNRB (0.46) | EDNRBEDNRA | |
| SCHEMBL8550952 | 0.81 | EDNRB (0.46) | EDNRBEDNRAALDH1A1KDM4E | |
| SCHEMBL8552494 | 0.80 | EDNRB (0.49) | EDNRBEDNRA | |
| SCHEMBL8551802 | 0.79 | EDNRB (0.39) | EDNRBEDNRAALDH1A1MAPTMEN1 | |
| SCHEMBL8552610 | 0.79 | EDNRB (0.46) | EDNRBEDNRAALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |