Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.48 |
| ▸ | HTR1F | P30939 | 3/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7483268 | 0.83 | HTR1D (0.70) | HTR1FHTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL8551986 | 0.82 | HTR1F (0.68) | HTR1FHTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL7485137 | 0.82 | HTR1D (0.69) | HTR1FHTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL8551530 | 0.81 | DRD2 (0.54) | HTR1DHTR1BDRD2HTR2ADRD3 | |
| SCHEMBL8548604 | 0.80 | HTR1F (0.46) | HTR1FHTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL8552921 | 0.80 | DRD2 (0.49) | MAPTHTR1DHTR1BDRD2HTR2A | |
| SCHEMBL8552841 | 0.79 | KMT2A (0.47) | MAPTTSHRMEN1RAB9AKMT2A | |
| SCHEMBL8552432 | 0.78 | RORC (0.51) | HTR1FHTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL8552447 | 0.78 | DRD2 (0.47) | HTR1DHTR1BDRD2HTR2ADRD3 | |
| SCHEMBL8381707 | 0.77 | MEN1 (0.47) | MAPTTSHRMEN1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| WO-1998015545-A1 | NEW SEROTONIN 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 1998-04-16 | — | — | WO | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |