Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.49 |
| ▸ | DRD4 | P21917 | 7/20 | 0.49 |
| ▸ | HTR1A | P08908 | 3/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 5/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | WNT1 | P04628 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8549897 | 0.84 | DRD2 (0.52) | DRD2DRD4HTR1ASLC6A4DRD3 | |
| SCHEMBL8545455 | 0.83 | DRD2 (0.50) | DRD2DRD4HTR1ADRD3HTR2A | |
| SCHEMBL8590734 | 0.80 | DRD2 (0.51) | DRD2DRD4HTR1ASLC6A4KCNH2 | |
| SCHEMBL8547063 | 0.78 | DRD4 (0.57) | DRD2DRD4HTR1ASLC6A4DRD3 | |
| SCHEMBL8550207 | 0.75 | DRD2 (0.56) | DRD2DRD4HTR1ASLC6A4DRD3 | |
| SCHEMBL8592270 | 0.74 | DRD2 (0.55) | DRD2DRD4HTR1ASLC6A4DRD3 | |
| SCHEMBL31663134 | 0.73 | DRD2 (0.47) | DRD2DRD4DRD3TLR9GSK3B | |
| SCHEMBL31663092 | 0.73 | DRD2 (0.47) | DRD2DRD4DRD3TLR9GSK3B | |
| SCHEMBL8548881 | 0.73 | DRD2 (0.46) | DRD2DRD4HTR1ASLC6A4DRD3 | |
| SCHEMBL8545948 | 0.72 | DRD2 (0.50) | DRD2DRD4HTR1ASLC6A4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0822814-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 1998-12-09 | — | — | EP | claimed |
| EP-0822814-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 1998-02-11 | — | — | EP | claimed |
| WO-1996032938-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1996-10-24 | — | — | WO | claimed |
| EP-0822814-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 1998-12-09 | — | — | EP | disclosed |
| EP-0822814-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 1998-02-11 | — | — | EP | disclosed |
| US-5668148-A | BENIGN PROSTATIC HYPERTROPHY | MERCK & CO., INC. (US) | 1997-09-16 | — | — | US | disclosed |
| WO-1996032938-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1996-10-24 | — | — | WO | disclosed |