Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.56 |
| ▸ | DRD4 | P21917 | 3/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8592270 | 0.91 | DRD2 (0.55) | DRD2DRD4SIGMAR1DRD3HRH3 | |
| SCHEMBL8547063 | 0.86 | DRD4 (0.57) | DRD2DRD4SIGMAR1DRD3GSK3B | |
| SCHEMBL8590734 | 0.84 | DRD2 (0.51) | DRD2DRD4SIGMAR1HRH3HTR1A | |
| SCHEMBL8546176 | 0.80 | POLB (0.47) | DRD2DRD4DRD3GSK3BHTR1A | |
| SCHEMBL8549897 | 0.77 | DRD2 (0.52) | DRD2DRD4SIGMAR1DRD3GSK3B | |
| SCHEMBL8548881 | 0.77 | DRD2 (0.46) | DRD2DRD4DRD3GSK3BHTR1A | |
| SCHEMBL8545455 | 0.76 | DRD2 (0.50) | DRD2DRD4DRD3HTR1A | |
| SCHEMBL8548381 | 0.75 | DRD2 (0.49) | DRD2DRD4DRD3GSK3BHTR1A | |
| SCHEMBL8549443 | 0.75 | HTR1A (0.55) | DRD2DRD4SIGMAR1DRD3HTR1A | |
| SCHEMBL1388576 | 0.74 | DRD2 (0.56) | DRD2DRD4SIGMAR1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0822814-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 1998-12-09 | — | — | EP | claimed |
| EP-0822814-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 1998-02-11 | — | — | EP | claimed |
| WO-1996032938-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1996-10-24 | — | — | WO | claimed |
| EP-0822814-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 1998-12-09 | — | — | EP | disclosed |
| EP-0822814-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 1998-02-11 | — | — | EP | disclosed |
| US-5668148-A | BENIGN PROSTATIC HYPERTROPHY | MERCK & CO., INC. (US) | 1997-09-16 | — | — | US | disclosed |
| WO-1996032938-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1996-10-24 | — | — | WO | disclosed |