Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | ACLY | P53396 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | METAP2 | P50579 | 2/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | FABP4 | P15090 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552433 | 0.86 | METAP2 (0.51) | ALDH1A1ACLYHPGDHSD17B10METAP2 | |
| SCHEMBL8492726 | 0.80 | CSNK2A1 (0.50) | ALDH1A1ACLYHPGDHSD17B10METAP2 | |
| SCHEMBL5706560 | 0.80 | CSNK2A1 (0.50) | ALDH1A1ACLYHPGDHSD17B10METAP2 | |
| SCHEMBL27909908 | 0.79 | CSNK2A1 (0.48) | ALDH1A1ACLYHPGDHSD17B10METAP2 | |
| SCHEMBL1725851 | 0.79 | CSNK2A1 (0.53) | ALDH1A1ACLYHPGDHSD17B10METAP2 | |
| SCHEMBL32664450 | 0.77 | GAA (0.48) | ALDH1A1CSNK2A1GAASMN1; SMN2LMNA | |
| SCHEMBL10868958 | 0.77 | GAA (0.48) | ALDH1A1CSNK2A1GAASMN1; SMN2LMNA | |
| SCHEMBL4433906 | 0.77 | CA1 (0.70) | ALDH1A1HPGDHSD17B10SMN1; SMN2MAPT | |
| SCHEMBL17319217 | 0.76 | LMNA (0.69) | ALDH1A1HPGDGAASMN1; SMN2LMNA | |
| SCHEMBL7763277 | 0.75 | CYP1A2 (0.40) | ALDH1A1ACLYHPGDHSD17B10METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0752990-B1 | BENZISOTHIAZOLES DERIVATIVES AS INHIBITORS OF 5-LIPOXYGENASE BIOSYNTHESIS | PFIZER (US) | 1998-08-05 | — | — | EP | disclosed |
| US-5665749-A | Benzisothiazoles derivatives as inhibitors of 5-lipoxygenase biosynthesis | PFIZER INC. (US) | 1997-09-09 | — | — | US | disclosed |
| EP-0752990-A1 | BENZISOTHIAZOLES DERIVATIVES AS INHIBITORS OF 5-LIPOXYGENASE BIOSYNTHESIS | PFIZER INC. (US) | 1997-01-15 | — | — | EP | disclosed |
| WO-1995026346-A1 | BENZISOTHIAZOLES DERIVATIVES AS INHIBITORS OF 5-LIPOXYGENASE BIOSYNTHESIS | PFIZER INC. (US) | 1995-10-05 | — | — | WO | disclosed |