Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.55 |
| ▸ | MAPT | P10636 | 7/20 | 0.55 |
| ▸ | LMNA | P02545 | 5/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2005010 | 0.75 | CA12 (0.81) | ALDH1A1MAPTLMNASMN1; SMN2TP53 | |
| SCHEMBL15705227 | 0.71 | ALDH1A1 (1.00) | ALDH1A1MAPTLMNASMN1; SMN2TP53 | |
| SCHEMBL930602 | 0.71 | MAPT (0.82) | ALDH1A1MAPTLMNASMN1; SMN2HPGD | |
| SCHEMBL1592808 | 0.71 | MAPT (0.82) | ALDH1A1MAPTLMNASMN1; SMN2HPGD | |
| SCHEMBL11026205 | 0.71 | CA12 (0.68) | ALDH1A1MAPTLMNASMN1; SMN2HPGD | |
| SCHEMBL9001311 | 0.70 | CA12 (0.72) | ALDH1A1MAPTLMNASMN1; SMN2TP53 | |
| SCHEMBL11705580 | 0.70 | MEN1 (0.86) | ALDH1A1MAPTLMNASMN1; SMN2TP53 | |
| SCHEMBL6928927 | 0.69 | PIM1 (0.67) | ALDH1A1MAPTLMNAHPGDCA2 | |
| SCHEMBL6928923 | 0.69 | PIM1 (0.67) | ALDH1A1MAPTLMNAHPGDCA2 | |
| SCHEMBL28170795 | 0.68 | MAPT (0.79) | ALDH1A1MAPTLMNASMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526658-B1 | THIAZOLIDINE-2,4-DIONE DERIVATIVE, SALT THEREOF, AND PRODUCTION OF THE SAME | KYORIN SEIYAKU KK (JP) | 1998-09-23 | — | — | EP | disclosed |
| US-5342850-A | Therapeutical agent for diabetes without adverse effect; aldose reductase inhibitor | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1994-08-30 | — | — | US | disclosed |
| EP-0526658-A1 | THIAZOLIDINE-2,4-DIONE DERIVATIVE, SALT THEREOF, AND PRODUCTION OF THE SAME | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1993-02-10 | — | — | EP | disclosed |