Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | HTR5A | P47898 | 1/20 | 0.41 |
| ▸ | F9 | P00740 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8548772 | 0.99 | MAPT (0.43) | MAPTLMNAKDM4ETSHRHSD17B10 | |
| SCHEMBL8549470 | 0.87 | MAPT (0.46) | MAPTLMNAKDM4ETSHRHSD17B10 | |
| SCHEMBL17996841 | 0.85 | ALDH1A1 (0.47) | MAPTLMNAKDM4ETSHRHSD17B10 | |
| SCHEMBL17996836 | 0.84 | MAPT (0.46) | MAPTLMNAKDM4ETSHRHSD17B10 | |
| SCHEMBL8544023 | 0.84 | HTR1A (0.48) | MAPTLMNATSHRHSD17B10HTR1A | |
| Hydrochloric Acid SCHEMBL6017128 | 0.84 | HTR1A (0.47) | MAPTLMNATSHRHSD17B10HTR1A | |
| SCHEMBL9206773 | 0.83 | KDM4E (0.38) | MAPTLMNAKDM4ETSHRHSD17B10 | |
| SCHEMBL17080814 | 0.83 | MAPT (0.49) | MAPTLMNA | |
| SCHEMBL8545029 | 0.82 | CYP2D6 (0.38) | MAPTLMNAKDM4ETSHRHSD17B10 | |
| SCHEMBL8545092 | 0.82 | PRMT1 (0.57) | MAPTLMNAHTR1ADRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0660832-B1 | SEROTONIN RECEPTOR AGENTS | MERRELL PHARMA INC (US) | 1998-01-14 | — | — | EP | disclosed |
| US-5436246-A | Compounds for treatment of anxiety, depression, migraine, stroke, angina and hypertension | MERRELL DOW PHARMACEUTICALS INC. | 1995-07-25 | — | — | US | disclosed |
| EP-0660832-A1 | SEROTONIN RECEPTOR AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1995-07-05 | — | — | EP | disclosed |
| WO-1994006789-A1 | SEROTONIN RECEPTOR AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-03-31 | — | — | WO | disclosed |