Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 4/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 2/20 | 0.43 |
| ▸ | HTR1B | P28222 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8544023 | 0.90 | HTR1A (0.48) | MAPTTSHRHSD17B10LMNAHTR1A | |
| Hydrochloric Acid SCHEMBL6017128 | 0.89 | HTR1A (0.47) | MAPTTSHRHSD17B10LMNAHTR1A | |
| SCHEMBL17996841 | 0.89 | ALDH1A1 (0.47) | MAPTTSHRHSD17B10LMNAHTR1A | |
| SCHEMBL17996836 | 0.88 | MAPT (0.46) | MAPTTSHRHSD17B10LMNAHTR1A | |
| SCHEMBL8548654 | 0.87 | MAPT (0.43) | MAPTTSHRHSD17B10LMNAHTR1A | |
| Hydrochloric Acid SCHEMBL8548772 | 0.86 | MAPT (0.43) | MAPTTSHRHSD17B10LMNAHTR1A | |
| SCHEMBL17080814 | 0.86 | MAPT (0.49) | MAPTLMNAALDH1A1L3MBTL1 | |
| SCHEMBL8545047 | 0.85 | HTR1A (0.53) | HTR1ASLC6A4ALDH1A1HTR1DHTR1B | |
| SCHEMBL8545092 | 0.85 | PRMT1 (0.57) | MAPTLMNAHTR1ASLC6A4ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8545546 | 0.85 | HTR1A (0.52) | HTR1ASLC6A4ALDH1A1HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0660832-B1 | SEROTONIN RECEPTOR AGENTS | MERRELL PHARMA INC (US) | 1998-01-14 | — | — | EP | disclosed |
| US-5436246-A | Compounds for treatment of anxiety, depression, migraine, stroke, angina and hypertension | MERRELL DOW PHARMACEUTICALS INC. | 1995-07-25 | — | — | US | disclosed |