Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.44 |
| ▸ | EYA3 | Q99504 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | THRB | P10828 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16540976 | 0.85 | MAPT (0.46) | NPC1KMT2ARAD52MAPTTHRB | |
| SCHEMBL8544477 | 0.81 | ALDH1A1 (0.61) | NPC1KMT2ASLC22A12POLBMAPT | |
| SCHEMBL679245 | 0.81 | ALDH1A1 (0.46) | NPC1SLC22A12LMNAHTTMAPT | |
| SCHEMBL27445438 | 0.78 | SMN1; SMN2 (0.46) | NPC1KMT2ALMNAHTTPOLB | |
| SCHEMBL8544863 | 0.78 | KDM4E (0.58) | NPC1KMT2ASLC22A12MAPTTP53 | |
| SCHEMBL8550034 | 0.78 | KDM4E (0.46) | NPC1KMT2ASLC22A12MAPTRAB9A | |
| SCHEMBL8841213 | 0.78 | KDM4E (0.41) | NPC1KMT2APOLBRAD52MAPT | |
| SCHEMBL16541035 | 0.78 | MAPT (0.48) | NPC1KMT2AHTTPOLBRAD52 | |
| SCHEMBL28217436 | 0.77 | NPC1 (0.58) | NPC1KMT2ASLC22A12EYA3LMNA | |
| SCHEMBL16540606 | 0.76 | KDM4E (0.53) | NPC1KMT2AHTTMAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623607-B1 | Benzofuranyl-and-thiophenyl-alkanecarboxyclic acid derivatives | BAYER AG (DE) | 1998-07-15 | — | — | EP | disclosed |
| US-5504213-A | ANTIINFLAMMATORY AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1996-04-02 | — | — | US | disclosed |
| EP-0623607-A1 | Benzofuranyl-and-thiophenyl-alkanecarboxyclic acid derivatives | BAYER AG (DE) | 1994-11-09 | — | — | EP | disclosed |