Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | EYA3 | Q99504 | 2/20 | 0.51 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.49 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28209634 | 0.88 | NPC1 (0.64) | NPC1KMT2ALMNAHTTRAB9A | |
| SCHEMBL9727655 | 0.86 | MAPT (0.61) | NPC1KMT2ALMNARAB9AMAPT | |
| SCHEMBL30608265 | 0.81 | NPC1 (0.61) | NPC1KMT2ARAB9AMAPTSMN1; SMN2 | |
| SCHEMBL30608268 | 0.80 | NPC1 (0.73) | NPC1KMT2AHTTRAB9AMAPT | |
| SCHEMBL5287590 | 0.80 | MCL1 (0.69) | KMT2ASMN1; SMN2MEN1ALDH1A1KCNH2 | |
| SCHEMBL11823271 | 0.79 | EYA3 (0.66) | NPC1KMT2AHTTRAB9AMAPT | |
| SCHEMBL9486692 | 0.79 | HTT (0.61) | NPC1KMT2ALMNAHTTRAB9A | |
| SCHEMBL8548676 | 0.77 | NPC1 (0.46) | NPC1KMT2ALMNAHTTRAB9A | |
| SCHEMBL28411136 | 0.77 | CASP3 (0.57) | NPC1KMT2ARAB9AMAPTMEN1 | |
| SCHEMBL28208744 | 0.77 | NPC1 (0.64) | NPC1KMT2ARAB9AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107935972-B | 5- [ 2-hydroxy-3- (isopropylamino) propoxy ] benzofuran derivative and application thereof | 沈阳药科大学 | 2020-06-02 | — | — | CN | claimed |
| CN-107935972-A | 5 [2 hydroxyl 3 (isopropylamine base) propoxyl group] benzofuran derivatives and its application | 沈阳药科大学 | 2018-04-20 | — | — | CN | claimed |
| CN-107935972-B | 5- [ 2-hydroxy-3- (isopropylamino) propoxy ] benzofuran derivative and application thereof | 沈阳药科大学 | 2020-06-02 | — | — | CN | disclosed |
| CN-107935972-A | 5 [2 hydroxyl 3 (isopropylamine base) propoxyl group] benzofuran derivatives and its application | 沈阳药科大学 | 2018-04-20 | — | — | CN | disclosed |