Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8548608 | 0.88 | MAPT (0.44) | KMT2AMEN1TDP1ALDH1A1MAPT | |
| SCHEMBL8551326 | 0.81 | ALDH1A1 (0.44) | KMT2AMEN1TDP1ALDH1A1MAPT | |
| SCHEMBL8548327 | 0.77 | ALDH1A1 (0.43) | KMT2AALDH1A1MAPTLMNANPSR1 | |
| Hydrochloric Acid SCHEMBL8550917 | 0.76 | PLAU (0.45) | KMT2AMEN1TDP1ALDH1A1MAPT | |
| SCHEMBL8550823 | 0.75 | ALDH1A1 (0.42) | KMT2AMEN1ALDH1A1MAPTLMNA | |
| SCHEMBL8550890 | 0.74 | ATM (0.55) | KMT2AMEN1TDP1ALDH1A1MAPT | |
| SCHEMBL8549262 | 0.74 | ALDH1A1 (0.41) | KMT2AMEN1ALDH1A1MAPTLMNA | |
| SCHEMBL8552241 | 0.74 | ALDH1A1 (0.41) | KMT2AMEN1ALDH1A1MAPTLMNA | |
| Hydrochloric Acid SCHEMBL8550910 | 0.74 | ABCG2 (0.39) | KMT2AMEN1TDP1ALDH1A1MAPT | |
| SCHEMBL8548603 | 0.71 | ALDH1A1 (0.50) | KMT2AMEN1TDP1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825187-A1 | Condensed pyridazinyl guanidines, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-25 | — | — | EP | disclosed |