Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8548778 | 0.88 | KMT2A (0.47) | MAPTNPSR1TDP1ALDH1A1L3MBTL1 | |
| SCHEMBL8552284 | 0.78 | PLAU (0.40) | MAPTNPSR1TDP1ALDH1A1MEN1 | |
| SCHEMBL8552276 | 0.77 | KDR (0.43) | MAPTNPSR1TDP1ALDH1A1MEN1 | |
| SCHEMBL8547799 | 0.76 | KMT2A (0.43) | MAPTNPSR1TDP1ALDH1A1L3MBTL1 | |
| SCHEMBL8550781 | 0.76 | ALDH1A1 (0.44) | MAPTNPSR1ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL8551326 | 0.75 | ALDH1A1 (0.44) | MAPTNPSR1TDP1ALDH1A1L3MBTL1 | |
| SCHEMBL8552718 | 0.74 | ALDH1A1 (0.42) | MAPTNPSR1ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL8551333 | 0.73 | ALDH1A1 (0.41) | MAPTNPSR1ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL7904780 | 0.72 | ALDH1A1 (0.60) | MAPTNPSR1ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL1736457 | 0.68 | PAX8 (0.57) | MAPTTDP1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825187-A1 | Condensed pyridazinyl guanidines, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-25 | — | — | EP | disclosed |