Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.72 |
| ▸ | RAB9A | P51151 | 8/20 | 0.72 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | MLYCD | O95822 | 1/20 | 0.63 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.62 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28489579 | 0.94 | NPC1 (0.72) | NPC1RAB9ASIGMAR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7705937 | 0.91 | ALDH1A1 (0.76) | NPC1RAB9ASIGMAR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL17372599 | 0.89 | NPC1 (0.65) | NPC1RAB9ASIGMAR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL17554117 | 0.87 | ABCG2 (0.63) | NPC1RAB9ASIGMAR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL30560465 | 0.87 | ABCG2 (0.63) | NPC1RAB9ASIGMAR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL16562164 | 0.86 | RAB9A (0.67) | NPC1RAB9ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL2335992 | 0.85 | KMT2A (0.71) | NPC1RAB9ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL3225126 | 0.85 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL6244424 | 0.84 | KMT2A (0.58) | NPC1RAB9ASIGMAR1SMN1; SMN2ALDH1A1 | |
| Iodide SCHEMBL30758593 | 0.84 | KMT2A (0.70) | NPC1RAB9ASMN1; SMN2ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112209847-A | Method for preparing amide compound under catalysis of ionic liquid in high-pressure environment | 烟台大学 | 2021-01-12 | — | — | CN | disclosed |
| EP-0526402-B1 | Heteroaryl substituted hydroxylamine derivatives as lipoxygenase inhibitors | CIBA GEIGY AG (CH) | 1998-01-21 | — | — | EP | disclosed |
| US-5350761-A | Lipoxygenase inhibitors as antiinflammatory agents and antiallergens | CIBA-GEIGY CORPORATION (US) | 1994-09-27 | — | — | US | disclosed |
| US-5334600-A | Lipoxygenase inhibitors | CIBA-GEIGY CORPORATION (US) | 1994-08-02 | — | — | US | disclosed |
| US-5260316-A | Lipoxygenase inhibitor | CIBA-GEIGY CORPORATION (US) | 1993-11-09 | — | — | US | disclosed |
| EP-0526402-A1 | Heteroaryl substituted hydroxylamine derivatives as lipoxygenase inhibitors | CIBA-GEIGY AG (CH) | 1993-02-03 | — | — | EP | disclosed |