Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 5/20 | 0.54 |
| ▸ | EDNRA | P25101 | 2/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552494 | 0.96 | EDNRB (0.49) | EDNRBEDNRAF2PLAUELANE | |
| SCHEMBL8549528 | 0.92 | EDNRB (0.45) | EDNRBEDNRAELANE | |
| SCHEMBL8552520 | 0.92 | EDNRB (0.46) | EDNRBEDNRAPLA2G2AF2PLAU | |
| SCHEMBL8548911 | 0.90 | EDNRB (0.46) | EDNRBEDNRAPLA2G2AF2PLAU | |
| SCHEMBL8552742 | 0.90 | EDNRB (0.43) | EDNRBEDNRAPLA2G2AELANE | |
| SCHEMBL8547652 | 0.88 | EDNRB (0.64) | EDNRBEDNRAPLA2G2A | |
| SCHEMBL8546234 | 0.88 | EDNRB (0.57) | EDNRBEDNRAPLA2G2A | |
| SCHEMBL8552639 | 0.87 | EDNRB (0.43) | EDNRBEDNRAF2PLAUELANE | |
| SCHEMBL8546118 | 0.87 | EDNRB (0.42) | EDNRBEDNRAPLA2G2AF2PLAU | |
| SCHEMBL8550789 | 0.86 | EDNRB (0.73) | EDNRBEDNRAPLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |