Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
| ▸ | C1R | P00736 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | TACR1 | P25103 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8549281 | 0.86 | KDM4E (0.35) | KDM4EPOLBMEN1KMT2AMAPT | |
| SCHEMBL8548499 | 0.86 | MEN1 (0.36) | MEN1KMT2AMAPTALDH1A1NPC1 | |
| SCHEMBL8548832 | 0.83 | KDM4E (0.44) | KDM4EPOLBMEN1KMT2AMAPT | |
| SCHEMBL8549279 | 0.81 | KDM4E (0.43) | KDM4EPOLBMEN1KMT2AMAPT | |
| SCHEMBL8544322 | 0.78 | KDM4E (0.53) | KDM4EPOLBMEN1KMT2AMAPT | |
| SCHEMBL9434976 | 0.76 | KDM4E (0.38) | KDM4EPOLBMEN1KMT2AMAPT | |
| SCHEMBL9318361 | 0.74 | AR (0.38) | KDM4EPOLBMEN1KMT2AMAPT | |
| SCHEMBL8550098 | 0.73 | MEN1 (0.39) | MEN1KMT2AMAPTALDH1A1NPC1 | |
| SCHEMBL9663251 | 0.73 | HSP90AA1 (0.41) | KDM4EPOLBMEN1KMT2AMAPT | |
| SCHEMBL9318636 | 0.72 | SLC6A3 (0.47) | KDM4EPOLBMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0514198-B1 | 1H-Imidazol-1-yl-methyl benzofuran derivatives with the imidazolyl moiety being substituted by a cycloalkyl group | GLAXO GROUP LTD (GB) | 1998-08-05 | — | — | EP | disclosed |
| US-5498722-A | HYPOTENSIVES | GLAXO GROUP (GB) | 1996-03-12 | — | — | US | disclosed |
| US-5332831-A | Angiotensin antagonist | GLAXO GROUP LIMITED (GB) | 1994-07-26 | — | — | US | disclosed |