Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PNMT | P11086 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8546836 | 0.85 | ADRB3 (0.56) | ADRB3ADRB1 | |
| SCHEMBL8542977 | 0.73 | ADRB3 (0.39) | ADRB3GRIN2BADRB1 | |
| SCHEMBL8540992 | 0.72 | AGTR2 (0.44) | ADRB3ADRB1 | |
| SCHEMBL9241816 | 0.68 | PNMT (0.46) | TSHRNFKB1PNMTADRB1 | |
| SCHEMBL11339022 | 0.68 | PNMT (0.46) | TSHRNFKB1PNMTADRB1 | |
| SCHEMBL178870 | 0.68 | MEN1 (0.55) | MAPT | |
| SCHEMBL178869 | 0.68 | MEN1 (0.55) | MAPT | |
| SCHEMBL7148443 | 0.67 | SMN1; SMN2 (0.50) | ADRB3MAPTSMN1; SMN2ADRB1 | |
| SCHEMBL10974609 | 0.67 | SMN1; SMN2 (0.50) | ADRB3MAPTSMN1; SMN2ADRB1 | |
| SCHEMBL11288086 | 0.67 | PNMT (0.44) | PNMTGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0608568-B1 | Aminocycloalkanobenzodioxoles as beta-3 selective adrenergic agents | AMERICAN CYANAMID CO (US) | 1998-03-11 | — | — | EP | disclosed |
| US-5594027-A | TREATMENT OF DIABETES, HYPERGLYCEMIA AND OBESITY | AMERICAN CYANAMID COMPANY (US) | 1997-01-14 | — | — | US | disclosed |
| US-5510376-A | TREATING DIABETES, HYPERGLYCEMIA, OBESITY | AMERICAN CYANAMID COMPANY (US) | 1996-04-23 | — | — | US | disclosed |
| EP-0608568-A1 | Aminocycloalkanobenzodioxoles as beta-3 selective adrenergic agents | AMERICAN CYANAMID COMPANY (US) | 1994-08-03 | — | — | EP | disclosed |