Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 12/20 | 0.61 |
| ▸ | EDNRA | P25101 | 9/20 | 0.52 |
| ▸ | CSF1R | P07333 | 3/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551194 | 0.92 | EDNRB (0.64) | EDNRBEDNRA | |
| SCHEMBL8553006 | 0.91 | EDNRB (0.62) | EDNRBEDNRA | |
| SCHEMBL8549015 | 0.89 | EDNRB (0.50) | EDNRBEDNRACSF1RPLK1 | |
| SCHEMBL8551023 | 0.88 | EDNRB (0.67) | EDNRBEDNRACSF1RPLK1 | |
| SCHEMBL8553492 | 0.87 | EDNRB (0.64) | EDNRBEDNRAPPARG | |
| SCHEMBL8551430 | 0.85 | EDNRB (0.80) | EDNRBEDNRAPPARG | |
| SCHEMBL8553793 | 0.85 | EDNRB (0.70) | EDNRBEDNRAPPARG | |
| SCHEMBL8547579 | 0.83 | EDNRB (0.64) | EDNRBEDNRA | |
| SCHEMBL8552685 | 0.81 | EDNRB (0.64) | EDNRBEDNRA | |
| SCHEMBL8550885 | 0.81 | EDNRB (0.74) | EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |