Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 8/20 | 0.62 |
| ▸ | EDNRA | P25101 | 5/20 | 0.53 |
| ▸ | PLA2G2A | P14555 | 9/20 | 0.43 |
| ▸ | PLA2G1B | P04054 | 5/20 | 0.43 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.41 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.41 |
| ▸ | PLA2G2E | Q9NZK7 | 2/20 | 0.41 |
| ▸ | PLA2G6 | O60733 | 1/20 | 0.40 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.40 |
| ▸ | PLA2G12B | Q9BX93 | 1/20 | 0.40 |
| ▸ | PLA2G12A | Q9BZM1 | 1/20 | 0.40 |
| ▸ | PLA2G2F | Q9BZM2 | 1/20 | 0.40 |
| ▸ | PLA2G3 | Q9NZ20 | 1/20 | 0.40 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551194 | 0.92 | EDNRB (0.64) | EDNRBEDNRAPLA2G2A | |
| SCHEMBL8549014 | 0.91 | EDNRB (0.61) | EDNRBEDNRA | |
| SCHEMBL8553011 | 0.89 | EDNRB (0.51) | EDNRBEDNRAPLA2G2APLA2G1BPLA2G10 | |
| SCHEMBL8553492 | 0.87 | EDNRB (0.64) | EDNRBEDNRA | |
| SCHEMBL8547579 | 0.84 | EDNRB (0.64) | EDNRBEDNRA | |
| SCHEMBL8552685 | 0.82 | EDNRB (0.64) | EDNRBEDNRA | |
| SCHEMBL8550885 | 0.82 | EDNRB (0.74) | EDNRBEDNRA | |
| SCHEMBL8551196 | 0.81 | EDNRB (0.52) | EDNRBEDNRAPLA2G2AKDM4EALDH1A1 | |
| SCHEMBL8589486 | 0.81 | EDNRB (0.53) | EDNRBEDNRA | |
| SCHEMBL8549171 | 0.81 | EDNRB (0.72) | EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |