Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL854924 | 0.79 | ALDH1A1 (0.44) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL8064140 | 0.77 | ALDH1A1 (0.44) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL21844929 | 0.77 | ALDH1A1 (0.42) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL11421284 | 0.77 | ALDH1A1 (0.44) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL4288310 | 0.77 | ALDH1A1 (0.42) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL1777530 | 0.76 | HTT (0.46) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL2095539 | 0.76 | RAPGEF4 (0.56) | ALDH1A1MAPTMEN1KMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL1811188 | 0.76 | ALDH1A1 (0.41) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL8943130 | 0.74 | MEN1 (0.42) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL14017786 | 0.74 | LMNA (0.41) | ALDH1A1MAPTLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1857443-B1 | Therapeutic morpholino-substituted compounds | ASTRAZENECA AB (SE) | 2012-03-28 | — | — | EP | claimed |
| JP-4820518-B2 | — | — | 2011-11-24 | — | — | JP | claimed |
| EP-1857443-A2 | Therapeutic morpholino-substituted compounds | AstraZeneca AB (SE) | 2007-11-21 | — | — | EP | claimed |
| US-6977255-B2 | Therapeutic morpholino-substituted compounds | KINACIA PTY. LTD. (AU) | 2005-12-20 | — | — | US | claimed |
| JP-2003530318-A | — | — | 2003-10-14 | — | — | JP | claimed |
| EP-1257537-A4 | THERAPEUTIC MORPHOLINO-SUBSTITUTED COMPOUNDS | KINACIA PTY LTD (AU) | 2003-04-23 | — | — | EP | claimed |
| EP-1257537-A1 | THERAPEUTIC MORPHOLINO-SUBSTITUTED COMPOUNDS | Kinacia Pty Ltd (AU) | 2002-11-20 | — | — | EP | claimed |
| WO-2001053266-A1 | THERAPEUTIC MORPHOLINO-SUBSTITUTED COMPOUNDS | KINACIA PTY LTD. (AU) | 2001-07-26 | — | — | WO | claimed |