SCHEMBL8549282

SCHEMBL8549282

COc1cc(Cl)nc(OCc2ccsc2)c1

nearest known ligand 0.40

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PARP15 Q460N3 1/20 0.39
PARP10 Q53GL7 1/20 0.39
PARP3 Q9Y6F1 1/20 0.39
GRM5 P41594 3/20 0.38
PDE2A O00408 1/20 0.38
FLT1 P17948 1/20 0.37
KDR P35968 1/20 0.37
NPC1 O15118 1/20 0.36
KIT P10721 1/20 0.36
PDGFRB P09619 3/20 0.36
PDGFRA P16234 3/20 0.36
PLK1 P53350 1/20 0.36
MCHR1 Q99705 2/20 0.35
MARS1 P56192 1/20 0.35
MRGPRX1 Q96LB2 1/20 0.34
PTGES O14684 1/20 0.34
ALOX5 P09917 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8546425 0.83 GRM5 (0.42) PARP15PARP10PARP3GRM5FLT1
SCHEMBL8551486 0.83 GRM5 (0.43) PARP15PARP10PARP3GRM5FLT1
SCHEMBL16727045 0.81 PDE2A (0.55) GRM5PDE2ANPC1
SCHEMBL8773184 0.80 MAOB (0.51) GRM5PDE2APDGFRBPDGFRAALOX5
SCHEMBL31287990 0.80 MAOB (0.51) GRM5PDE2APDGFRBPDGFRAALOX5
SCHEMBL8547120 0.80 GRM5 (0.38) PARP15PARP10PARP3GRM5FLT1
SCHEMBL8550364 0.80 GRM5 (0.38) PARP15PARP10PARP3GRM5FLT1
SCHEMBL8546508 0.80 GRM5 (0.38) PARP15PARP10PARP3GRM5FLT1
SCHEMBL8549682 0.77 GRM5 (0.37) PARP15PARP10PARP3GRM5FLT1
SCHEMBL8546238 0.77 GRM5 (0.64) PARP15PARP10PARP3GRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0693490-B1 2-Phenoxy-6-thienylmethyloxypyridine derivative, process for producing the same, and herbicidal composition KUREHA CHEMICAL IND CO LTD (JP) 1998-09-09 EP disclosed
US-5624942-A 2-phenoxy-6-thienylmethyloxypyridine derivative and herbicidal composition containing same KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1997-04-29 US disclosed
EP-0693490-A1 2-Phenoxy-6-thienylmethyloxypyridine derivative, process for producing the same, and herbicidal composition KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1996-01-24 EP disclosed