SCHEMBL8546508

SCHEMBL8546508

CNc1cc(Cl)nc(OCc2ccsc2)c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 4/20 0.38
NUDT1 P36639 1/20 0.36
PARP15 Q460N3 1/20 0.35
PARP10 Q53GL7 1/20 0.35
PARP3 Q9Y6F1 1/20 0.35
PIM1 P11309 1/20 0.35
CLK1 P49759 1/20 0.35
CDK9 P50750 1/20 0.35
DYRK1A Q13627 1/20 0.35
DYRK2 Q92630 1/20 0.35
DYRK1B Q9Y463 1/20 0.35
FLT1 P17948 1/20 0.35
KDR P35968 1/20 0.35
NPC1 O15118 2/20 0.35
MRGPRX1 Q96LB2 1/20 0.34
PTGES O14684 1/20 0.33
ALOX5 P09917 1/20 0.33
PABPC1 P11940 1/20 0.33
MCHR1 Q99705 1/20 0.31
S1PR2 O95136 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8546425 0.82 GRM5 (0.42) GRM5PARP15PARP10PARP3PIM1
SCHEMBL8551486 0.82 GRM5 (0.43) GRM5PARP15PARP10PARP3PIM1
SCHEMBL8549282 0.80 PARP15 (0.39) GRM5PARP15PARP10PARP3FLT1
SCHEMBL8547120 0.79 GRM5 (0.38) GRM5PARP15PARP10PARP3PIM1
SCHEMBL8550364 0.79 GRM5 (0.38) GRM5PARP15PARP10PARP3PIM1
SCHEMBL8546238 0.76 GRM5 (0.64) GRM5PARP15PARP10PARP3
SCHEMBL8549682 0.76 GRM5 (0.37) GRM5PARP15PARP10PARP3FLT1
SCHEMBL8551819 0.75 CYP11B1 (0.41) GRM5PARP15PARP10PARP3FLT1
SCHEMBL8545730 0.74 L3MBTL1 (0.44) KDRRAB9A
SCHEMBL8547127 0.71 PARP15 (0.35) GRM5PARP15PARP10PARP3PIM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0693490-B1 2-Phenoxy-6-thienylmethyloxypyridine derivative, process for producing the same, and herbicidal composition KUREHA CHEMICAL IND CO LTD (JP) 1998-09-09 EP disclosed
US-5624942-A 2-phenoxy-6-thienylmethyloxypyridine derivative and herbicidal composition containing same KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1997-04-29 US disclosed
EP-0693490-A1 2-Phenoxy-6-thienylmethyloxypyridine derivative, process for producing the same, and herbicidal composition KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1996-01-24 EP disclosed