SCHEMBL8549682

SCHEMBL8549682

FC(F)(F)c1cc(Cl)nc(OCc2ccsc2)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 3/20 0.37
POLB P06746 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
PARP15 Q460N3 1/20 0.35
PARP10 Q53GL7 1/20 0.35
PARP3 Q9Y6F1 1/20 0.35
NR1H4 Q96RI1 1/20 0.35
HDAC1 Q13547 2/20 0.34
HDAC6 Q9UBN7 2/20 0.34
HDAC5 Q9UQL6 1/20 0.34
MRGPRX4 Q96LA9 3/20 0.33
NR3C1 P04150 1/20 0.33
FLT1 P17948 1/20 0.33
KDR P35968 1/20 0.33
TACR1 P25103 4/20 0.33
SLC6A4 P31645 4/20 0.33
KCNH2 Q12809 4/20 0.33
IDO1 P14902 1/20 0.32
GABRA1 P14867 1/20 0.32
GABRG2 P18507 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8551486 0.82 GRM5 (0.43) GRM5L3MBTL1PARP15PARP10PARP3
SCHEMBL8546425 0.80 GRM5 (0.42) GRM5POLBPARP15PARP10PARP3
SCHEMBL8545000 0.78 L3MBTL1 (0.47) POLBL3MBTL1MRGPRX4
SCHEMBL8549282 0.77 PARP15 (0.39) GRM5PARP15PARP10PARP3FLT1
SCHEMBL8550364 0.76 GRM5 (0.38) GRM5PARP15PARP10PARP3FLT1
SCHEMBL8546508 0.76 GRM5 (0.38) GRM5PARP15PARP10PARP3FLT1
SCHEMBL8546238 0.76 GRM5 (0.64) GRM5PARP15PARP10PARP3
SCHEMBL8547120 0.76 GRM5 (0.38) GRM5PARP15PARP10PARP3FLT1
SCHEMBL8550799 0.76 L3MBTL1 (0.45) POLBL3MBTL1MRGPRX4
SCHEMBL8551819 0.75 CYP11B1 (0.41) GRM5PARP15PARP10PARP3HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0693490-B1 2-Phenoxy-6-thienylmethyloxypyridine derivative, process for producing the same, and herbicidal composition KUREHA CHEMICAL IND CO LTD (JP) 1998-09-09 EP disclosed
US-5624942-A 2-phenoxy-6-thienylmethyloxypyridine derivative and herbicidal composition containing same KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1997-04-29 US disclosed
EP-0693490-A1 2-Phenoxy-6-thienylmethyloxypyridine derivative, process for producing the same, and herbicidal composition KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1996-01-24 EP disclosed