Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.39 |
| ▸ | HTR1D | P28221 | 5/20 | 0.39 |
| ▸ | HTR2A | P28223 | 5/20 | 0.39 |
| ▸ | HTR1A | P08908 | 3/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8550144 | 0.77 | DRD2 (0.50) | DRD2HTR1DHTR2AHTR1ADRD4 | |
| SCHEMBL8550575 | 0.76 | DRD2 (0.49) | DRD2HTR1DHTR2AHTR1ADRD4 | |
| SCHEMBL8550482 | 0.76 | DRD2 (0.49) | DRD2HTR1DHTR2AHTR1ADRD4 | |
| SCHEMBL8548703 | 0.75 | DRD2 (0.48) | DRD2HTR1DHTR2AHTR1ADRD4 | |
| SCHEMBL8549609 | 0.75 | DRD4 (0.58) | DRD2HTR1DHTR2AHTR1ADRD4 | |
| SCHEMBL8554232 | 0.74 | DRD2 (0.47) | DRD2HTR1DHTR2AHTR1ADRD4 | |
| SCHEMBL8550532 | 0.74 | DRD2 (0.47) | DRD2HTR1DHTR2AHTR1ADRD4 | |
| SCHEMBL8554951 | 0.74 | LMNA (0.47) | DRD2HTR1DHTR2AHTR1ADRD4 | |
| SCHEMBL8549749 | 0.74 | HTR2A (0.47) | DRD2HTR1DHTR2AHTR1ADRD4 | |
| SCHEMBL8550003 | 0.72 | HTR2A (0.48) | DRD2HTR1DHTR2AHTR1ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0836599-A1 | 1,6-DISUBSTITUTED ISOCHROMANS FOR TREATMENT OF MIGRAINE HEADACHES | PHARMACIA & UPJOHN COMPANY (US) | 1998-04-22 | — | — | EP | disclosed |