Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 7/20 | 0.59 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.59 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.59 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.59 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.59 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.59 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.59 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.59 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.59 |
| ▸ | OGT | O15294 | 1/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8544337 | 0.94 | GRIN2B (0.57) | GRIN2BGRIN1GRIN2DGRIN3BADRA1D | |
| SCHEMBL8549047 | 0.91 | GRIN1 (0.63) | GRIN2BGRIN1GRIN2DGRIN3BADRA1D | |
| SCHEMBL8547674 | 0.90 | GRIN2B (0.55) | GRIN2BGRIN1GRIN2DGRIN3BADRA1D | |
| SCHEMBL8872102 | 0.90 | GRIN2B (0.55) | GRIN2BGRIN1GRIN2DGRIN3BADRA1D | |
| SCHEMBL10835876 | 0.87 | GRIN2B (0.54) | GRIN2BOGT | |
| SCHEMBL8544748 | 0.85 | GRIN2B (0.58) | GRIN2BGRIN1GRIN2DGRIN3BADRA1D | |
| SCHEMBL8547312 | 0.85 | MAOA (0.54) | GRIN2BGRIN1GRIN2DGRIN3BADRA1D | |
| SCHEMBL8546412 | 0.85 | GRIN2B (0.50) | GRIN2BGRIN1GRIN2DGRIN3BADRA1D | |
| Hydrochloric Acid SCHEMBL8542941 | 0.85 | MEN1 (0.56) | GRIN2BGRIN1GRIN2DGRIN3BADRA1D | |
| SCHEMBL10838656 | 0.85 | GRIN2B (0.51) | GRIN2BADRA1DADRA1AADRA1BMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709384-B1 | Benzylpiperidine derivatives having high affinity for binding sites of aminoacid receptors | MERCK PATENT GMBH (DE) | 1998-12-23 | — | — | EP | disclosed |
| EP-0709384-A1 | Benzylpiperidine derivatives having high affinity for binding sites of aminoacid receptors | MERCK PATENT GmbH (DE) | 1996-05-01 | — | — | EP | disclosed |
| US-4619932-A | CENTRAL NERVOUS SYSTEM CONTROLLERS; ANTI-SCHIZOPHRENIA AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-10-28 | — | — | US | disclosed |
| US-4567187-A | CENTRAL NERVOUS SYSTEM | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-01-28 | — | — | US | disclosed |
| US-4460593-A | Carbostyril derivatives, and central nervous system controlling agents containing the carbostyril derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-07-17 | — | — | US | disclosed |
| US-4455422-A | ANTIHISTAMINES, CNS CONTROLLERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-06-19 | — | — | US | disclosed |