Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 5/20 | 0.51 |
| ▸ | KDM1A | O60341 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
| ▸ | DRD2 | P14416 | 3/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10835876 | 0.85 | GRIN2B (0.54) | GRIN2BKDM1AKCNH2DRD2HTR2A | |
| SCHEMBL8549343 | 0.85 | GRIN2B (0.59) | GRIN2BADRA1DADRA1AADRA1BMAOA | |
| SCHEMBL10836282 | 0.82 | ALDH1A1 (0.56) | GRIN2BKCNH2DRD2HTR2AHTR1A | |
| SCHEMBL9768289 | 0.82 | GRIN2B (0.57) | GRIN2BKDM1AKCNH2DRD2HTR2A | |
| SCHEMBL10838660 | 0.81 | GRIN2B (0.48) | GRIN2BKDM1AKCNH2DRD2HTR2A | |
| SCHEMBL15586378 | 0.81 | DRD2 (0.51) | KDM1ADRD2ADRA1DSLC6A4ADRA1A | |
| SCHEMBL10836115 | 0.80 | KCNH2 (0.66) | GRIN2BKCNH2DRD2SLC6A4HTR2A | |
| SCHEMBL8544337 | 0.79 | GRIN2B (0.57) | GRIN2BADRA1DADRA1AADRA1BMAOA | |
| SCHEMBL8872102 | 0.79 | GRIN2B (0.55) | GRIN2BKCNH2DRD2ADRA1DADRA1A | |
| SCHEMBL8547674 | 0.79 | GRIN2B (0.55) | GRIN2BKCNH2DRD2ADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4619932-A | CENTRAL NERVOUS SYSTEM CONTROLLERS; ANTI-SCHIZOPHRENIA AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-10-28 | — | — | US | disclosed |
| US-4567187-A | CENTRAL NERVOUS SYSTEM | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-01-28 | — | — | US | disclosed |
| US-4460593-A | Carbostyril derivatives, and central nervous system controlling agents containing the carbostyril derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-07-17 | — | — | US | disclosed |
| US-4455422-A | ANTIHISTAMINES, CNS CONTROLLERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-06-19 | — | — | US | disclosed |