Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.56 |
| ▸ | HTR1D | P28221 | 2/20 | 0.56 |
| ▸ | HTR2C | P28335 | 2/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | GABRP | O00591 | 1/20 | 0.37 |
| ▸ | GABRD | O14764 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4013102 | 0.82 | PTPN1 (0.54) | PTPN1CDK2MAPTMEN1KMT2A | |
| SCHEMBL2227476 | 0.73 | HTR1A (0.59) | HTR1AHTR1DHTR2CMTNR1B | |
| SCHEMBL8950172 | 0.73 | HTR1A (0.59) | HTR1AHTR1DHTR2CPTPN1MTNR1B | |
| SCHEMBL4010048 | 0.73 | PTPN1 (0.57) | PTPN1MAPTMEN1KMT2ANPC1 | |
| SCHEMBL11597123 | 0.73 | CYP1A2 (0.60) | MAPTMEN1KMT2ALOXL2 | |
| SCHEMBL3844656 | 0.73 | CYP1A2 (0.60) | MAPTMEN1KMT2ALOXL2 | |
| Hydrochloric Acid SCHEMBL7148554 | 0.72 | HTR1D (0.57) | HTR1AHTR1DHTR2CMAPTRAB9A | |
| SCHEMBL7834882 | 0.72 | HTR1A (0.78) | HTR1AHTR1DHTR2CMEN1KMT2A | |
| SCHEMBL5222516 | 0.71 | CYP3A4 (0.53) | MAPTMEN1KMT2ARAB9ALOXL2 | |
| SCHEMBL20718830 | 0.71 | ALDH1A1 (0.50) | MAPTMEN1KMT2ALOXL2LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| WO-1998015545-A1 | NEW SEROTONIN 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 1998-04-16 | — | — | WO | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |