Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | WEE1 | P30291 | 4/20 | 0.38 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.38 |
| ▸ | CCNK | O75909 | 1/20 | 0.37 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.37 |
| ▸ | NQO2 | P16083 | 2/20 | 0.36 |
| ▸ | NQO1 | P15559 | 2/20 | 0.36 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 2/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28056 | 0.89 | KIT (0.45) | KITPDGFRAFGFR3WEE1AOX1 | |
| SCHEMBL29435144 | 0.89 | KIT (0.45) | KITPDGFRAFGFR3WEE1AOX1 | |
| SCHEMBL29371790 | 0.89 | KIT (0.45) | KITPDGFRAFGFR3WEE1AOX1 | |
| Hydrochloric Acid SCHEMBL29613355 | 0.88 | KIT (0.45) | KITPDGFRAFGFR3WEE1AOX1 | |
| Hydrochloric Acid SCHEMBL5953239 | 0.88 | KIT (0.45) | KITPDGFRAFGFR3WEE1AOX1 | |
| SCHEMBL8542307 | 0.84 | KIT (0.48) | KITPDGFRAFGFR3NQO2NQO1 | |
| SCHEMBL7640244 | 0.81 | KIT (0.45) | KITPDGFRAFGFR3WEE1AOX1 | |
| SCHEMBL27118310 | 0.80 | POLB (0.46) | KITPDGFRAFGFR3CCNKCDK12 | |
| SCHEMBL8548702 | 0.80 | LMNA (0.45) | POLBGAA | |
| SCHEMBL24277141 | 0.79 | ALDH1A1 (0.40) | KITPDGFRAFGFR3CCNKCDK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0591058-B1 | Ellipticine derivatives with antitumor activity | ADIR (FR) | 1998-06-03 | — | — | EP | disclosed |
| US-5498611-A | ANTITUMOR AGENTS | ADIR ET COMPAGNIE (FR) | 1996-03-12 | — | — | US | disclosed |
| US-5407940-A | Antitumor agents | ADIR ET COMPAGNIE (FR) | 1995-04-18 | — | — | US | disclosed |
| EP-0591058-A1 | Ellipticine derivatives with antitumor activity | ADIR ET COMPAGNIE (FR) | 1994-04-06 | — | — | EP | disclosed |