Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 4/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 3/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8549843 | 0.91 | DRD4 (0.46) | DRD4DRD3DRD2MAPTHTR2A | |
| SCHEMBL8550849 | 0.85 | DRD4 (0.46) | DRD4DRD2MAPTHTR2A | |
| SCHEMBL8550263 | 0.83 | DRD4 (0.48) | DRD4DRD2HTR2A | |
| SCHEMBL8553551 | 0.83 | DRD4 (0.48) | DRD4DRD2ADRA1AHTR2A | |
| SCHEMBL8551575 | 0.83 | DRD4 (0.48) | DRD4DRD2HTR2A | |
| SCHEMBL8550687 | 0.83 | DRD4 (0.48) | DRD4DRD2ADRA1AMAPTHTR2A | |
| SCHEMBL8549471 | 0.83 | DRD4 (0.48) | HTR7DRD4DRD3DRD2MAPT | |
| SCHEMBL8549757 | 0.83 | DRD3 (0.59) | DRD3DRD2ADRA1AMAPTHTR2A | |
| SCHEMBL8550252 | 0.82 | DRD4 (0.59) | DRD4DRD3DRD2HTR2A | |
| SCHEMBL8550036 | 0.81 | DRD4 (0.47) | DRD4DRD2GAAMAPTHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0836599-A1 | 1,6-DISUBSTITUTED ISOCHROMANS FOR TREATMENT OF MIGRAINE HEADACHES | PHARMACIA & UPJOHN COMPANY (US) | 1998-04-22 | — | — | EP | claimed |
| EP-0836599-A1 | 1,6-DISUBSTITUTED ISOCHROMANS FOR TREATMENT OF MIGRAINE HEADACHES | PHARMACIA & UPJOHN COMPANY (US) | 1998-04-22 | — | — | EP | disclosed |