Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 18/20 | 0.44 |
| ▸ | HTR2A | P28223 | 17/20 | 0.44 |
| ▸ | DRD3 | P35462 | 17/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8549862 | 0.86 | DRD2 (0.38) | DRD2HTR2ADRD3SLC6A4 | |
| SCHEMBL8553525 | 0.84 | DRD2 (0.43) | DRD2SLC6A4KDM4ENPC1ALDH1A1 | |
| SCHEMBL7481590 | 0.84 | HTR1D (0.56) | DRD2 | |
| SCHEMBL8383438 | 0.82 | MTNR1A (0.38) | DRD2HTR2ADRD3KDM4ENPC1 | |
| SCHEMBL8383440 | 0.82 | MTNR1A (0.38) | DRD2HTR2ADRD3KDM4ENPC1 | |
| SCHEMBL8552345 | 0.81 | DRD2 (0.54) | DRD2HTR2ADRD3SLC6A4 | |
| SCHEMBL8548355 | 0.81 | DRD2 (0.47) | DRD2HTR2ADRD3SLC6A4 | |
| SCHEMBL8703719 | 0.80 | DRD2 (0.53) | DRD2HTR2ADRD3SLC6A4 | |
| SCHEMBL8551462 | 0.80 | DRD2 (0.53) | DRD2HTR2ADRD3SLC6A4 | |
| SCHEMBL8551459 | 0.80 | DRD2 (0.53) | DRD2HTR2ADRD3SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| WO-1998015545-A1 | NEW SEROTONIN 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 1998-04-16 | — | — | WO | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |