Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | BUB1 | O43683 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8548391 | 0.93 | ALDH1A1 (0.35) | ALDH1A1TSHRMKNK2TP53MEN1 | |
| SCHEMBL8548985 | 0.90 | ALDH1A1 (0.33) | ALDH1A1TSHRMKNK2TP53MEN1 | |
| SCHEMBL8548830 | 0.89 | ALDH1A1 (0.33) | ALDH1A1TSHRMKNK2TP53MEN1 | |
| SCHEMBL8544134 | 0.86 | — | — | |
| SCHEMBL8549059 | 0.85 | ALDH1A1 (0.38) | ALDH1A1TSHRMEN1KMT2ABUB1 | |
| SCHEMBL9309104 | 0.84 | MKNK2 (0.34) | MKNK2TP53ADORA3ADORA2AADORA1 | |
| SCHEMBL9310413 | 0.82 | MKNK2 (0.33) | MKNK2ADORA3ADORA2AADORA1BRD4 | |
| SCHEMBL9429517 | 0.81 | ALDH1A1 (0.36) | ALDH1A1TSHRTP53MEN1KMT2A | |
| SCHEMBL8544767 | 0.79 | — | — | |
| SCHEMBL9309256 | 0.78 | AGTR1 (0.38) | MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0514198-B1 | 1H-Imidazol-1-yl-methyl benzofuran derivatives with the imidazolyl moiety being substituted by a cycloalkyl group | GLAXO GROUP LTD (GB) | 1998-08-05 | — | — | EP | disclosed |
| US-5498722-A | HYPOTENSIVES | GLAXO GROUP (GB) | 1996-03-12 | — | — | US | disclosed |
| US-5332831-A | Angiotensin antagonist | GLAXO GROUP LIMITED (GB) | 1994-07-26 | — | — | US | disclosed |
| EP-0514198-A1 | 1H-Imidazol-1-yl-methyl benzofuran derivatives with the imidazolyl moiety being substituted by a cycloalkyl group | GLAXO GROUP LIMITED (GB) | 1992-11-19 | — | — | EP | disclosed |