SCHEMBL8550194

SCHEMBL8550194

O=Cc1ccc(Oc2cccc(Oc3ccc(C=O)c(C(F)(F)F)c3)c2)cc1C(F)(F)F

nearest known ligand 0.44

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
AR P10275 7/20 0.44
POLB P06746 2/20 0.41
MAPT P10636 2/20 0.41
ALDH1A1 P00352 3/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
GAA P10253 2/20 0.39
KMT2A Q03164 2/20 0.39
MEN1 O00255 1/20 0.39
MITF O75030 1/20 0.39
GFER P55789 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
NLRP1 Q9C000 1/20 0.39
NOD2 Q9HC29 1/20 0.39
SCN9A Q15858 1/20 0.37
MGLL Q99685 1/20 0.36
LMNA P02545 1/20 0.36
ERN1 O75460 1/20 0.35
KIF11 P52732 1/20 0.35
MAOB P27338 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18957656 0.92 LMNA (0.46) ARMAPTALDH1A1L3MBTL1GAA
SCHEMBL875821 0.91 POLB (0.51) ARPOLBMAPTALDH1A1L3MBTL1
SCHEMBL15096324 0.90 AR (0.59) ARALDH1A1L3MBTL1GAAGFER
SCHEMBL7070347 0.88 AR (0.48) AR
SCHEMBL6142741 0.85 SCN9A (0.44) ARPOLBMAPTALDH1A1L3MBTL1
SCHEMBL883449 0.84 CHEK2 (0.46) ARSCN9A
SCHEMBL15823461 0.84 AR (0.56) ARALDH1A1SMN1; SMN2ERN1MAOB
SCHEMBL321663 0.79 ALDH1A1 (0.58) MAPTALDH1A1L3MBTL1GAAKMT2A
SCHEMBL3718244 0.79 GPR3 (0.41) POLBMAPTALDH1A1GAASMN1; SMN2
SCHEMBL15096322 0.79 MEN1 (0.40) ARPOLBKMT2AMEN1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0696585-B1 NOVEL BISOXADIAZOLIDINE DERIVATIVE YAMANOUCHI PHARMA CO LTD (JP) 1998-12-16 EP disclosed
US-5643931-A ANTIDIABETIC AGENTS YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1997-07-01 US disclosed
EP-0696585-A1 NOVEL BISOXADIAZOLIDINE DERIVATIVE YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1996-02-14 EP disclosed