Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 3/20 | 0.34 |
| ▸ | DRD2 | P14416 | 3/20 | 0.34 |
| ▸ | DRD1 | P21728 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 2/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7411687 | 0.88 | MAOA (0.40) | DRD2DRD1KMT2AKDM4EDRD4 | |
| SCHEMBL7416842 | 0.83 | DRD1 (0.40) | DRD2DRD1DRD4MAOA | |
| Oxalic Acid SCHEMBL7414373 | 0.83 | DRD1 (0.37) | DRD2DRD1SLC6A2SLC6A4MAOA | |
| Hydrochloric Acid SCHEMBL7422696 | 0.83 | DRD2 (0.39) | DRD2DRD1DRD4MAOA | |
| Bromide SCHEMBL8543859 | 0.83 | DRD2 (0.39) | DRD2DRD1KDM4EDRD4MAOA | |
| SCHEMBL8971978 | 0.72 | DRD1 (0.41) | DRD2DRD1DRD4 | |
| SCHEMBL8549052 | 0.71 | ALDH1A1 (0.35) | DRD2DRD1KMT2AKDM4EMEN1 | |
| SCHEMBL7417594 | 0.70 | MAOA (0.41) | DRD2DRD1KMT2AKDM4EDRD4 | |
| SCHEMBL8747354 | 0.70 | TRPV1 (0.48) | DRD2DRD1KMT2AKDM4EMAOA | |
| SCHEMBL8747278 | 0.69 | POLB (0.39) | KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5807868-A | ANALGESICS; PSYCHOLOGICAL DISORDES; PARKINSON*S DIESASE;COGNITION ACTIVATORS; DRUG DEPENDENCE; DYSKINESIA | KNOLL AKTIENGESELLSCHAFT (DE) | 1998-09-15 | — | — | US | disclosed |
| US-5804586-A | ANALGESICS, PSYCHOLOGICAL DISORDERS | KNOLL AKTIENGESELLSCHAFT (DE) | 1998-09-08 | — | — | US | disclosed |
| EP-0707570-B1 | ISOQUINOLINE DERIVATIVES AS THERAPEUTIC AGENTS | KNOLL AG (DE) | 1998-05-06 | — | — | EP | disclosed |