Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8550252 | 0.89 | DRD4 (0.59) | DRD4DRD2DRD3HRH3HTR1A | |
| SCHEMBL8553551 | 0.82 | DRD4 (0.48) | DRD4DRD2HRH3SLC6A4HTR1A | |
| SCHEMBL8549471 | 0.82 | DRD4 (0.48) | DRD4DRD2DRD3HRH3HTR1A | |
| SCHEMBL8551575 | 0.82 | DRD4 (0.48) | DRD4DRD2HRH3HTR1AUSP2 | |
| SCHEMBL8550687 | 0.82 | DRD4 (0.48) | DRD4DRD2HRH3HTR1ASMN1; SMN2 | |
| SCHEMBL8627744 | 0.82 | DRD4 (0.51) | DRD4DRD2DRD3HRH3HTR1A | |
| SCHEMBL8550428 | 0.81 | ALDH1A1 (0.52) | DRD4DRD2DRD3SLC6A4HTR1A | |
| SCHEMBL8549100 | 0.81 | DRD4 (0.47) | DRD4DRD2HRH3HTR1ASMN1; SMN2 | |
| SCHEMBL8550036 | 0.81 | DRD4 (0.47) | DRD4DRD2HRH3HTR1ASMN1; SMN2 | |
| SCHEMBL8549609 | 0.80 | DRD4 (0.58) | DRD4DRD2HTR1AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0836599-A1 | 1,6-DISUBSTITUTED ISOCHROMANS FOR TREATMENT OF MIGRAINE HEADACHES | PHARMACIA & UPJOHN COMPANY (US) | 1998-04-22 | — | — | EP | disclosed |