Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | PARP1 | P09874 | 9/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.54 |
| ▸ | PIM1 | P11309 | 2/20 | 0.54 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.54 |
| ▸ | KDM4A | O75164 | 1/20 | 0.47 |
| ▸ | KDM4B | O94953 | 1/20 | 0.47 |
| ▸ | KDM5C | P41229 | 1/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.47 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.47 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.46 |
| ▸ | TEK | Q02763 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8782182 | 0.88 | ACVR1 (0.57) | PARP1CHEK1PIM1ACVR1AKT1 | |
| SCHEMBL12476626 | 0.78 | PARP1 (0.62) | ALDH1A1PARP1CHEK1PIM1RPS6KA3 | |
| SCHEMBL6922381 | 0.76 | PARP1 (0.63) | ALDH1A1PARP1CHEK1PIM1RPS6KA3 | |
| SCHEMBL4973091 | 0.76 | PARP1 (0.56) | ALDH1A1PARP1CHEK1PIM1RPS6KA3 | |
| SCHEMBL13266881 | 0.74 | PARP1 (0.55) | ALDH1A1PARP1CHEK1PIM1RPS6KA3 | |
| SCHEMBL643424 | 0.74 | ALDH1A1 (1.00) | ALDH1A1PARP1CHEK1PIM1RPS6KA3 | |
| SCHEMBL29898482 | 0.74 | ALDH1A1 (1.00) | ALDH1A1PARP1CHEK1PIM1RPS6KA3 | |
| SCHEMBL28223920 | 0.73 | PARP1 (0.54) | ALDH1A1PARP1CHEK1PIM1RPS6KA3 | |
| SCHEMBL30101160 | 0.72 | PARP1 (0.57) | ALDH1A1PARP1CHEK1PIM1RPS6KA3 | |
| SCHEMBL14143352 | 0.72 | PARP1 (0.62) | ALDH1A1PARP1CHEK1PIM1RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880517-A1 | QUINAZOLINE COMPOUNDS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997030044-A1 | QUINAZOLINE COMPOUNDS | ZENECA LIMITED (GB) | 1997-08-21 | — | — | WO | disclosed |