Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 8/20 | 0.57 |
| ▸ | PARP1 | P09874 | 7/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.54 |
| ▸ | AKT1 | P31749 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.54 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.54 |
| ▸ | IP6K1 | Q92551 | 3/20 | 0.50 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.49 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8550755 | 0.88 | ALDH1A1 (0.58) | ACVR1PARP1CHEK1PIM1AKT1 | |
| SCHEMBL8622180 | 0.84 | ACVR1 (0.73) | ACVR1PARP1CHEK1PIM1AKT1 | |
| SCHEMBL7980737 | 0.78 | ACVR1 (0.67) | ACVR1PARP1CHEK1PIM1AKT1 | |
| SCHEMBL6773430 | 0.77 | ACVR1 (0.53) | ACVR1PARP1CHEK1PIM1AKT1 | |
| SCHEMBL13820309 | 0.76 | PARP1 (0.78) | ACVR1PARP1CHEK1PIM1AKT1 | |
| SCHEMBL8782197 | 0.76 | ACVR1 (0.63) | ACVR1PARP1CHEK1PIM1AKT1 | |
| SCHEMBL12441754 | 0.75 | PARP1 (0.60) | ACVR1PARP1CHEK1PIM1AKT1 | |
| SCHEMBL7980108 | 0.74 | QPCT (0.65) | ACVR1PARP1CHEK1PIM1AKT1 | |
| SCHEMBL30669818 | 0.74 | QPCT (0.65) | ACVR1PARP1CHEK1PIM1AKT1 | |
| SCHEMBL6869415 | 0.73 | ACVR1 (0.63) | ACVR1PARP1CHEK1PIM1AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0794953-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-09-17 | — | — | EP | disclosed |
| WO-1996016960-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-06-06 | — | — | WO | disclosed |