Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.51 |
| ▸ | DRD3 | P35462 | 4/20 | 0.51 |
| ▸ | DRD4 | P21917 | 4/20 | 0.51 |
| ▸ | HTR6 | P50406 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NCF1 | P14598 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8546517 | 0.99 | DRD2 (0.50) | DRD2DRD3DRD4HTR6MEN1 | |
| SCHEMBL8544808 | 0.88 | MEN1 (0.51) | DRD2MEN1KMT2AADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL6017322 | 0.87 | CYP2C9 (0.50) | DRD2MEN1KMT2AADRA1DADRA1A | |
| SCHEMBL6017105 | 0.86 | OPRM1 (0.50) | DRD2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL8546495 | 0.85 | OPRM1 (0.49) | DRD2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL6017149 | 0.84 | DRD4 (0.47) | DRD2DRD3DRD4MEN1KMT2A | |
| SCHEMBL9050996 | 0.81 | HTR1A (0.44) | DRD2DRD3DRD4ADRA1DADRA1A | |
| SCHEMBL6017224 | 0.81 | HTR1A (0.49) | DRD2ADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL6017117 | 0.81 | DRD2 (0.47) | DRD2DRD3ADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL8550084 | 0.80 | HTR1A (0.48) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0660832-B1 | SEROTONIN RECEPTOR AGENTS | MERRELL PHARMA INC (US) | 1998-01-14 | — | — | EP | disclosed |
| US-5436246-A | Compounds for treatment of anxiety, depression, migraine, stroke, angina and hypertension | MERRELL DOW PHARMACEUTICALS INC. | 1995-07-25 | — | — | US | disclosed |
| EP-0660832-A1 | SEROTONIN RECEPTOR AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1995-07-05 | — | — | EP | disclosed |
| WO-1994006789-A1 | SEROTONIN RECEPTOR AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-03-31 | — | — | WO | disclosed |