Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | CCR8 | P51685 | 1/20 | 0.59 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8554468 | 0.99 | MEN1 (0.58) | MEN1TSHRKMT2ACCR8ABL1 | |
| SCHEMBL2794872 | 0.84 | ALDH1A1 (0.63) | MEN1TSHRKMT2ACCR8ABL1 | |
| SCHEMBL8551044 | 0.82 | MEN1 (0.59) | MEN1TSHRKMT2ACCR8ABL1 | |
| Hydrochloric Acid SCHEMBL8550696 | 0.81 | MEN1 (0.58) | MEN1TSHRKMT2ACCR8ABL1 | |
| SCHEMBL22483452 | 0.81 | MEN1 (0.58) | MEN1TSHRKMT2ACCR8ABL1 | |
| SCHEMBL608528 | 0.81 | ALDH1A1 (0.76) | TSHRKMT2ACCR8POLBALDH1A1 | |
| SCHEMBL27608094 | 0.81 | MEN1 (0.69) | MEN1TSHRKMT2AABL1RIN1 | |
| SCHEMBL1519223 | 0.81 | MEN1 (0.69) | MEN1TSHRKMT2AABL1RIN1 | |
| SCHEMBL2050353 | 0.80 | MEN1 (0.57) | MEN1TSHRKMT2ACCR8ABL1 | |
| SCHEMBL15994613 | 0.80 | KMT2A (0.57) | MEN1TSHRKMT2ACCR8ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0871613-A1 | BENZYL PIPERIDINE DERIVATIVES AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 1998-10-21 | — | — | EP | disclosed |
| US-5753679-A | SCIZOPHRENIA | HOFFMANN-LA ROCHE INC. (US) | 1998-05-19 | — | — | US | disclosed |
| WO-1996035666-A1 | BENZYL PIPERIDINE DERIVATIVES AS PHARMACEUTICAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 1996-11-14 | — | — | WO | disclosed |