SCHEMBL8551065

SCHEMBL8551065

O=C(OC1CCN(Cc2ccc(Cl)cc2)CC1)c1ccc(Cl)cc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD4 P21917 3/20 0.60
DRD2 P14416 2/20 0.60
L3MBTL1 Q9Y468 1/20 0.53
TEAD1 P28347 1/20 0.53
LMNA P02545 2/20 0.52
CYP2D6 P10635 1/20 0.52
CYP2C19 P33261 1/20 0.52
DRD3 P35462 1/20 0.51
KDM4E B2RXH2 2/20 0.50
SCN1A P35498 1/20 0.50
SCN2A Q99250 1/20 0.50
SCN3A Q9NY46 1/20 0.50
GAA P10253 1/20 0.50
MAPT P10636 1/20 0.50
HPGD P15428 1/20 0.50
POLB P06746 1/20 0.50
GLA P06280 1/20 0.50
BCHE P06276 1/20 0.50
MEN1 O00255 1/20 0.49
KMT2A Q03164 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8550602 0.99 DRD2 (0.58) DRD4DRD2L3MBTL1TEAD1LMNA
SCHEMBL8550198 0.95 ADRB2 (0.57) DRD4DRD2GAA
SCHEMBL8549980 0.94 GPR183 (0.60) DRD4DRD2L3MBTL1TEAD1LMNA
Hydrochloric Acid SCHEMBL8551048 0.94 ADRB2 (0.56) DRD4DRD2L3MBTL1GAA
SCHEMBL8553670 0.94 SCN1A (0.61) DRD4DRD2L3MBTL1TEAD1LMNA
SCHEMBL8550706 0.93 DRD2 (0.62) DRD4DRD2LMNADRD3POLB
SCHEMBL8553033 0.93 DRD2 (0.70) DRD4DRD2LMNADRD3POLB
Hydrochloric Acid SCHEMBL8550815 0.92 GPR183 (0.58) DRD4DRD2L3MBTL1TEAD1LMNA
Hydrochloric Acid SCHEMBL27561716 0.92 SCN1A (0.60) DRD4DRD2L3MBTL1TEAD1LMNA
Hydrochloric Acid SCHEMBL8552585 0.92 DRD2 (0.61) DRD4DRD2LMNADRD3POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1084329-C Benzyl piepridine derivs as pharmaceutical agents HOFFMANN LA ROCHE (CH) 2002-05-08 CN claimed
EP-0871613-A1 BENZYL PIPERIDINE DERIVATIVES AS PHARMACEUTICAL AGENTS F. HOFFMANN-LA ROCHE AG (CH) 1998-10-21 EP claimed
US-5753679-A SCIZOPHRENIA HOFFMANN-LA ROCHE INC. (US) 1998-05-19 US claimed
WO-1996035666-A1 BENZYL PIPERIDINE DERIVATIVES AS PHARMACEUTICAL AGENTS F.HOFFMANN-LA ROCHE AG (CH) 1996-11-14 WO claimed
CN-1084329-C Benzyl piepridine derivs as pharmaceutical agents HOFFMANN LA ROCHE (CH) 2002-05-08 CN disclosed
EP-0871613-A1 BENZYL PIPERIDINE DERIVATIVES AS PHARMACEUTICAL AGENTS F. HOFFMANN-LA ROCHE AG (CH) 1998-10-21 EP disclosed
CN-1183768-A Benzyl piepridine derivs as pharmaceutical agents HOFFMANN LA ROCHE (CH) 1998-06-03 CN disclosed
US-5753679-A SCIZOPHRENIA HOFFMANN-LA ROCHE INC. (US) 1998-05-19 US disclosed
WO-1996035666-A1 BENZYL PIPERIDINE DERIVATIVES AS PHARMACEUTICAL AGENTS F.HOFFMANN-LA ROCHE AG (CH) 1996-11-14 WO disclosed