SCHEMBL8551105

SCHEMBL8551105

CCOC(=O)COc1ccc(CCC(=O)O)cc1

nearest known ligand 0.64

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.63
L3MBTL1 Q9Y468 1/20 0.63
GAA P10253 1/20 0.57
NPSR1 Q6W5P4 1/20 0.57
FFAR1 O14842 10/20 0.56
FFAR4 Q5NUL3 3/20 0.55
ABCB1 P08183 1/20 0.54
CYP4F2 P78329 1/20 0.54
CYP4A11 Q02928 1/20 0.54
KDM4E B2RXH2 1/20 0.51
ALDH1A1 P00352 1/20 0.51
TP53 P04637 1/20 0.51
MAPT P10636 1/20 0.51
HPGD P15428 1/20 0.51
HSD17B10 Q99714 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16695953 0.88 CYP4F2 (0.62) LMNAL3MBTL1GAANPSR1FFAR1
SCHEMBL781522 0.86 LMNA (0.54) LMNAL3MBTL1FFAR1FFAR4
SCHEMBL1586881 0.84 FFAR1 (0.63) LMNAL3MBTL1FFAR1FFAR4
SCHEMBL6375038 0.84 CYP4F2 (0.66) GAANPSR1ABCB1CYP4F2CYP4A11
SCHEMBL8554939 0.84 GAA (0.68) GAANPSR1KDM4EALDH1A1TP53
SCHEMBL1205605 0.84 LMNA (0.75) LMNAL3MBTL1FFAR1FFAR4
SCHEMBL1587300 0.84 CYP4F2 (0.74) LMNAL3MBTL1FFAR1CYP4F2CYP4A11
SCHEMBL8550447 0.84 ABCB1 (0.57) GAANPSR1FFAR1FFAR4ABCB1
SCHEMBL7723659 0.83 GAA (0.59) GAANPSR1CYP4F2CYP4A11KDM4E
SCHEMBL11817150 0.83 PPARA (0.63) GAANPSR1KDM4EALDH1A1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5817677-A ANTITHROMBOSIS AGENTS DR. KARL THOMAE GMBH (DE) 1998-10-06 US disclosed
EP-0858457-A1 5-MEMBERED HETEROCYCLES, PHARMACEUTICAL AGENTS CONTAINING SAID COMPOUNDS AND THE USE THEREOF AND METHODS OF PRODUCING THEM Dr. Karl Thomae GmbH (DE) 1998-08-19 EP disclosed
WO-1997015567-A1 5-MEMBERED HETEROCYCLES, PHARMACEUTICAL AGENTS CONTAINING SAID COMPOUNDS AND THE USE THEREOF AND METHODS OF PRODUCING THEM DR. KARL THOMAE GMBH (DE) 1997-05-01 WO disclosed