Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 16/20 | 0.46 |
| ▸ | HTR2A | P28223 | 15/20 | 0.46 |
| ▸ | DRD3 | P35462 | 15/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | UBE2M | P61081 | 1/20 | 0.39 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8708281 | 0.90 | DRD2 (0.45) | DRD2HTR2ADRD3SLC6A4 | |
| SCHEMBL8548789 | 0.82 | UBE2M (0.39) | DRD2TRPV1UBE2MDCUN1D1SLC6A4 | |
| SCHEMBL7486843 | 0.82 | HTR1D (0.52) | DRD2 | |
| SCHEMBL8548196 | 0.80 | DRD2 (0.52) | DRD2HTR2ADRD3SLC6A4 | |
| SCHEMBL8709640 | 0.75 | DRD2 (0.53) | DRD2HTR2ADRD3SLC6A4 | |
| SCHEMBL8707306 | 0.74 | DRD2 (0.52) | DRD2HTR2ADRD3SLC6A4 | |
| SCHEMBL8594882 | 0.74 | DRD2 (0.45) | DRD2HTR2ADRD3 | |
| SCHEMBL8548017 | 0.73 | DRD2 (0.50) | DRD2HTR2ADRD3SLC6A4 | |
| SCHEMBL8548534 | 0.73 | DRD2 (0.48) | DRD2HTR2ADRD3MEN1KMT2A | |
| SCHEMBL8553620 | 0.72 | DRD2 (0.46) | DRD2HTR2ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |