Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | NEK2 | P51955 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.33 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | NEK6 | Q9HC98 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL854104 | 0.84 | ALOX5 (0.38) | EPAS1NUAK1IGF1RMETPIM1 | |
| SCHEMBL854144 | 0.84 | PIM1 (0.37) | ALDH1A1EPAS1POLBNUAK1IGF1R | |
| SCHEMBL855174 | 0.78 | ABCC9 (0.39) | EPAS1NUAK1IGF1RMETPIM1 | |
| SCHEMBL855516 | 0.76 | EPAS1 (0.34) | ALDH1A1EPAS1NUAK1IGF1RMET | |
| SCHEMBL16555552 | 0.71 | EPAS1 (0.34) | EPAS1NUAK1IGF1RMETPIM1 | |
| SCHEMBL30365884 | 0.70 | KCNJ1 (0.44) | ALDH1A1GAA | |
| SCHEMBL855133 | 0.70 | KCNJ1 (0.44) | ALDH1A1GAA | |
| SCHEMBL12553039 | 0.70 | NUAK1 (0.41) | ALDH1A1EPAS1NUAK1IGF1RMET | |
| SCHEMBL18036757 | 0.70 | EPAS1 (0.60) | EPAS1PTGS1 | |
| SCHEMBL855628 | 0.69 | NUAK1 (0.35) | ALDH1A1EPAS1NUAK1IGF1RMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8604221-B2 | Production method of halogen-substituted phthalide | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2013-12-10 | — | — | US | disclosed |
| US-20120142946-A1 | PRODUCTION METHOD OF HALOGEN-SUBSTITUTED PHTHALIDE | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-06-07 | — | — | US | disclosed |
| EP-2433933-A1 | PRODUCTION METHOD OF HALOGEN-SUBSTITUTED PHTHALIDE | Sumitomo Chemical Company, Limited (JP) | 2012-03-28 | — | — | EP | disclosed |