Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R2 | Q9NPC1 | 12/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 7/20 | 0.40 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8553682 | 0.91 | LTB4R2 (0.49) | LTB4R2AGTR1AGTR2 | |
| SCHEMBL8551398 | 0.88 | AGTR1 (0.53) | AGTR1AGTR2 | |
| SCHEMBL8551839 | 0.86 | LTB4R2 (0.42) | LTB4R2AGTR1AGTR2 | |
| SCHEMBL8553595 | 0.80 | LTB4R2 (0.45) | LTB4R2AGTR1AGTR2ALDH1A1 | |
| SCHEMBL8548779 | 0.79 | LTB4R2 (0.48) | LTB4R2AGTR1AGTR2 | |
| SCHEMBL8553533 | 0.78 | LTB4R2 (0.45) | LTB4R2AGTR1AGTR2 | |
| SCHEMBL8551396 | 0.78 | AGTR1 (0.38) | AGTR1AGTR2 | |
| SCHEMBL8553684 | 0.78 | AGTR1 (0.65) | AGTR1AGTR2 | |
| SCHEMBL8552462 | 0.76 | LTB4R2 (0.49) | LTB4R2AGTR1 | |
| SCHEMBL8548489 | 0.76 | LTB4R2 (0.49) | LTB4R2AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0588299-B1 | 1,2,4-Oxadiazolyl- or 1,2,4-thiadiazolyl-biphenyl derivatives as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1998-07-01 | — | — | EP | disclosed |
| EP-0829479-A1 | Heterocyclic compounds and their use as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-03-18 | — | — | EP | disclosed |
| US-5500427-A | ANGIOTENSIN II ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-03-19 | — | — | US | disclosed |
| EP-0588299-A2 | 1,2,4-Oxadiazolyl- or 1,2,4-thiadiazolyl-biphenyl derivatives as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-03-23 | — | — | EP | disclosed |