Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R2 | Q9NPC1 | 12/20 | 0.45 |
| ▸ | AGTR1 | P30556 | 5/20 | 0.40 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.40 |
| ▸ | GNRHR | P30968 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6606838 | 0.87 | AGTR1 (0.53) | AGTR1AGTR2KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL8548779 | 0.83 | LTB4R2 (0.48) | LTB4R2AGTR1AGTR2 | |
| SCHEMBL8551839 | 0.80 | LTB4R2 (0.42) | LTB4R2AGTR1AGTR2 | |
| SCHEMBL8551369 | 0.80 | LTB4R2 (0.41) | LTB4R2AGTR1AGTR2ALDH1A1 | |
| SCHEMBL6606668 | 0.77 | KDM4E (0.55) | AGTR1AGTR2KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL8551883 | 0.74 | LTB4R2 (0.49) | LTB4R2AGTR1FFAR1AKR1B1KDM4E | |
| SCHEMBL8552171 | 0.74 | MAP2K1 (0.40) | AGTR1AGTR2KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL8875659 | 0.73 | LTB4R2 (0.42) | LTB4R2AGTR1AGTR2FFAR1AKR1B1 | |
| SCHEMBL8873498 | 0.72 | LTB4R2 (0.41) | LTB4R2AGTR1FFAR1AKR1B1ALDH1A1 | |
| SCHEMBL6606990 | 0.72 | AGTR1 (0.57) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0588299-B1 | 1,2,4-Oxadiazolyl- or 1,2,4-thiadiazolyl-biphenyl derivatives as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1998-07-01 | — | — | EP | disclosed |
| EP-0829479-A1 | Heterocyclic compounds and their use as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-03-18 | — | — | EP | disclosed |
| US-5500427-A | ANGIOTENSIN II ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-03-19 | — | — | US | disclosed |
| EP-0588299-A2 | 1,2,4-Oxadiazolyl- or 1,2,4-thiadiazolyl-biphenyl derivatives as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-03-23 | — | — | EP | disclosed |