Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 13/20 | 0.38 |
| ▸ | AGTR2 | P50052 | 8/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8553680 | 0.90 | AGTR1 (0.37) | AGTR1AGTR2 | |
| SCHEMBL6609722 | 0.86 | HTT (0.41) | AGTR1AGTR2 | |
| SCHEMBL6606955 | 0.86 | AGTR1 (0.51) | AGTR1AGTR2NPC1RAB9A | |
| SCHEMBL6604852 | 0.85 | AGTR2 (0.36) | AGTR1AGTR2TP53 | |
| SCHEMBL8944158 | 0.79 | JMJD6 (0.39) | AGTR1AGTR2TP53JMJD6 | |
| SCHEMBL6608135 | 0.78 | AGTR1 (0.47) | AGTR1AGTR2 | |
| SCHEMBL8551369 | 0.78 | LTB4R2 (0.41) | AGTR1AGTR2 | |
| SCHEMBL6605990 | 0.78 | BRS3 (0.39) | AGTR1AGTR2 | |
| SCHEMBL6610008 | 0.77 | AGTR1 (0.39) | AGTR1AGTR2TP53NPC1RAB9A | |
| SCHEMBL8551398 | 0.77 | AGTR1 (0.53) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0588299-B1 | 1,2,4-Oxadiazolyl- or 1,2,4-thiadiazolyl-biphenyl derivatives as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1998-07-01 | — | — | EP | disclosed |
| EP-0829479-A1 | Heterocyclic compounds and their use as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-03-18 | — | — | EP | disclosed |
| US-5500427-A | ANGIOTENSIN II ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-03-19 | — | — | US | disclosed |
| EP-0588299-A2 | 1,2,4-Oxadiazolyl- or 1,2,4-thiadiazolyl-biphenyl derivatives as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-03-23 | — | — | EP | disclosed |