SCHEMBL8551370

SCHEMBL8551370

BrCc1nc(CCCCCc2ccccc2)cs1

nearest known ligand 0.51

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 5/20 0.51
HDAC6 Q9UBN7 5/20 0.51
NOS1 P29475 1/20 0.47
DHFR P00374 3/20 0.43
CYP2D6 P10635 1/20 0.41
PDE5A O76074 1/20 0.41
PDE1A P54750 1/20 0.41
PDE1B Q01064 1/20 0.41
PDE1C Q14123 1/20 0.41
SIGMAR1 Q99720 6/20 0.40
MAOA P21397 1/20 0.38
MAPT P10636 1/20 0.38
RXFP1 Q9HBX9 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL201216 0.89 NOS1 (0.60) HDAC1HDAC6NOS1DHFR
SCHEMBL8553088 0.84 HDAC1 (0.54) HDAC1HDAC6NOS1DHFRCYP2D6
SCHEMBL2705651 0.80 HDAC1 (0.48) HDAC1HDAC6NOS1
SCHEMBL396385 0.76 MAPT (0.56) HDAC1HDAC6NOS1CYP2D6MAPT
SCHEMBL1809552 0.76 HDAC1 (0.51) HDAC1HDAC6NOS1CYP2D6PDE5A
SCHEMBL15522839 0.73 HDAC1 (0.55) HDAC1HDAC6PDE5APDE1APDE1B
SCHEMBL8214495 0.72 NOS1 (0.65) HDAC1HDAC6NOS1DHFR
SCHEMBL25714760 0.70 NOS1 (0.61) HDAC1HDAC6NOS1DHFRMAPT
SCHEMBL19956579 0.69 HDAC1 (0.57) HDAC1HDAC6NOS1
SCHEMBL8538010 0.69 HDAC6 (0.47) HDAC1HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0865429-A1 AZETIDINONE COMPOUNDS FOR THE TREATMENT OF ATHEROSCLEROSIS SMITHKLINE BEECHAM PLC (GB) 1998-09-23 EP disclosed
WO-1997021676-A1 AZETIDINONE COMPOUNDS FOR THE TREATMENT OF ATHEROSCLEROSIS SMITHKLINE BEECHAM PLC (GB) 1997-06-19 WO disclosed