Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.54 |
| ▸ | NOS1 | P29475 | 1/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | PDE1A | P54750 | 1/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 2/20 | 0.40 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551370 | 0.84 | HDAC1 (0.51) | HDAC1HDAC6NOS1PDE5APDE1A | |
| SCHEMBL8641341 | 0.83 | HDAC1 (0.47) | HDAC1HDAC6NOS1PDE5APDE1A | |
| SCHEMBL15522839 | 0.76 | HDAC1 (0.55) | HDAC1HDAC6PDE5APDE1APDE1B | |
| SCHEMBL396385 | 0.76 | MAPT (0.56) | HDAC1HDAC6NOS1CYP2D6MAPT | |
| SCHEMBL1809552 | 0.76 | HDAC1 (0.51) | HDAC1HDAC6NOS1PDE5APDE1A | |
| SCHEMBL27426865 | 0.75 | SLC6A3 (0.43) | HDAC1HDAC6 | |
| SCHEMBL10918996 | 0.73 | HDAC1 (0.58) | HDAC1HDAC6NOS1MAPT | |
| SCHEMBL201216 | 0.72 | NOS1 (0.60) | HDAC1HDAC6NOS1DHFR | |
| SCHEMBL8214495 | 0.72 | NOS1 (0.65) | HDAC1HDAC6NOS1DHFR | |
| SCHEMBL15522909 | 0.72 | HDAC1 (0.67) | HDAC1HDAC6PDE5APDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865429-A1 | AZETIDINONE COMPOUNDS FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1998-09-23 | — | — | EP | disclosed |
| WO-1997021676-A1 | AZETIDINONE COMPOUNDS FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-06-19 | — | — | WO | disclosed |