Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 18/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 17/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16644962 | 0.76 | HDAC1 (0.42) | HDAC6HDAC1 | |
| SCHEMBL8538449 | 0.75 | MAPT (0.54) | — | |
| SCHEMBL8044281 | 0.75 | GABRA5 (0.41) | HDAC6HDAC1GABRA5GABRB2HSD17B10 | |
| SCHEMBL2655261 | 0.75 | GABRA5 (0.68) | HDAC6HDAC1GABRA5GABRB2HSD17B10 | |
| SCHEMBL201216 | 0.72 | NOS1 (0.60) | HDAC6HDAC1 | |
| SCHEMBL30967897 | 0.71 | HDAC6 (0.45) | HDAC6HDAC1 | |
| SCHEMBL5512924 | 0.71 | SLC6A3 (0.47) | HDAC6HDAC1GABRA5GABRB2HSD17B10 | |
| SCHEMBL9408051 | 0.71 | LMNA (0.55) | HDAC6HDAC1HSD17B10 | |
| SCHEMBL743961 | 0.71 | MMP13 (0.57) | HDAC6HDAC1 | |
| SCHEMBL9096766 | 0.70 | CA2 (0.42) | HDAC6HDAC1GABRA5GABRB2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719140-A | ANALGESICS, PROSTAGLANDIN-E2 ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |
| EP-0696283-B1 | 2-, 3-, 4-, 5-, 6-, 7-, 8-, 9- AND/OR 10-SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | SEARLE & CO (US) | 1997-09-17 | — | — | EP | disclosed |
| EP-0696283-A1 | 2-, 3-, 4-, 5-, 6-, 7-, 8-, 9- AND/OR 10-SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | SEARLE & CO (US) | 1996-02-14 | — | — | EP | disclosed |
| US-5395932-A | Analgesics, prostaglandin E2 inhibitors | G. D. SEARLE & CO. (US) | 1995-03-07 | — | — | US | disclosed |
| WO-1994025456-A1 | 2-, 3-, 4-, 5-, 6-, 7-, 8-, 9- AND/OR 10-SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | G.D. SEARLE & CO. (US) | 1994-11-10 | — | — | WO | disclosed |