Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.37 |
| ▸ | RAF1 | P04049 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | GCGR | P47871 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7500519 | 0.81 | PTGS2 (0.62) | PTGS2PTGS1 | |
| SCHEMBL7503181 | 0.79 | PTGS2 (0.61) | PTGS2PTGS1 | |
| SCHEMBL6695860 | 0.73 | MAPK14 (0.52) | PTGS2PTGS1MAPK14MAPK11MAPK13 | |
| SCHEMBL1387188 | 0.73 | MAPK14 (0.65) | PTGS2PTGS1MAPK14MAPK11MAPK9 | |
| SCHEMBL16993493 | 0.73 | MAPK14 (0.65) | PTGS2PTGS1MAPK14MAPK11MAPK9 | |
| SCHEMBL7503500 | 0.73 | MAPK14 (0.52) | PTGS2PTGS1MAPK14MAPK11MAPK13 | |
| SCHEMBL9025437 | 0.72 | PTGS2 (0.45) | PTGS2PTGS1MAPK14MAPK11MAPK13 | |
| SCHEMBL3089251 | 0.71 | NR4A2 (0.45) | MAPK14MAPK11MAPK9MAPK13MAPK12 | |
| SCHEMBL8549078 | 0.71 | PTGS2 (0.40) | PTGS2PTGS1MAPK14MAPK11MAPK9 | |
| SCHEMBL3100353 | 0.70 | MAPK14 (0.44) | MAPK14MAPK11MAPK9MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825989-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-03-04 | — | — | EP | disclosed |